Dissociation encompasses changes in a series of phenotypes: colony and cell morphology. inmunological and biochemical reactions and virulence. The concept is generally associated to the in vitro transition between smooth (S) and rough (R) colonies. a phenotypic observation in Gram-negative bacteria commonly made since the beginning of microbiology as a science. https://cosmeticssquadets.shop/product-category/face-exfoliant/