IntroductionTo investigate the effects of hepatic arterial infusion chemotherapy (HAIC) with or without systemic chemotherapy compared to systemic chemotherapy alone in patients with locally advanced hepatocellular carcinoma (HCC). MethodsFollowing a registered protocol (PROSPERO 2023 CRD42023386780 Available from: https://www. crd. https://macorners.shop/product-category/bracelet-premium-box/