Summary: The synergistic effect of alcohol and HCV mediated through TLR4 signaling transactivates NANOG. a pluripotency transcription factor important for the stemness of tumor-initiating stem-like cells (TICs). NANOG together with the PRC2 complex suppresses expression of oxidative phosphorylation (OXPHOS) genes to generate TICs. The phosphodegron sequence PEST domain of NANOG binds ... https://spencertifieders.shop/product-category/headphone-amplifiers/